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Fig. 7. Molecular docking results of main components of AR and ASR. (A) Quercetin - IL-6; (B) magnolol - <t>JAK2;</t> (C) riligustilide - JAK2; (D) coniferyl ferulate - STAT3; (E) valerophenone - STAT3.
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Fig. 7. Molecular docking results of main components of AR and ASR. (A) Quercetin - IL-6; (B) magnolol - <t>JAK2;</t> (C) riligustilide - JAK2; (D) coniferyl ferulate - STAT3; (E) valerophenone - STAT3.
Rabbit Polyclonal Anti Total Ampk, supplied by Abcam, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 7. Molecular docking results of main components of AR and ASR. (A) Quercetin - IL-6; (B) magnolol - <t>JAK2;</t> (C) riligustilide - JAK2; (D) coniferyl ferulate - STAT3; (E) valerophenone - STAT3.
Anti Total Jak2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 7. Molecular docking results of main components of AR and ASR. (A) Quercetin - IL-6; (B) magnolol - JAK2; (C) riligustilide - JAK2; (D) coniferyl ferulate - STAT3; (E) valerophenone - STAT3.

Journal: Chinese Journal of Analytical Chemistry

Article Title: Active substances and molecular mechanisms of Astragali Radix and Angelicae Sinensis Radix against idiopathic pulmonary fibrosis effects by network pharmacology and in vitro experiments

doi: 10.1016/j.cjac.2024.100397

Figure Lengend Snippet: Fig. 7. Molecular docking results of main components of AR and ASR. (A) Quercetin - IL-6; (B) magnolol - JAK2; (C) riligustilide - JAK2; (D) coniferyl ferulate - STAT3; (E) valerophenone - STAT3.

Article Snippet: The primary antibodies in western blot were as follows: Anti ‐α- MA (catalog number: 19,245), anti ‐STAT3 (catalog number: 12640S), nti ‐phospho ‐STAT3 (catalog number: 9145S), anti ‐total ‐JAK2 (catalog umber: 3230S), anti ‐phospho ‐JAK2 (catalog number: 3771S) antibodes were obtained from Cell Signaling Technology (Danvers, MA).

Techniques:

Fig. 9. Effects of quercetin and magnolol on the JAK2/STAT3 signaling pathway in the A549 cells. Data are expressed as mean ± tan- dard error of the mean (SEM) ( n = 3/group). # p < 0.05 vs. Con group. ## p < 0.01 vs. Con group. ∗ p < 0.05 vs. IL-6 group. ∗ ∗ p < 0.01 vs. IL-6 group. △p < 0.05 vs. Magnolol group. △△p < 0.01 vs. Magnolol group.

Journal: Chinese Journal of Analytical Chemistry

Article Title: Active substances and molecular mechanisms of Astragali Radix and Angelicae Sinensis Radix against idiopathic pulmonary fibrosis effects by network pharmacology and in vitro experiments

doi: 10.1016/j.cjac.2024.100397

Figure Lengend Snippet: Fig. 9. Effects of quercetin and magnolol on the JAK2/STAT3 signaling pathway in the A549 cells. Data are expressed as mean ± tan- dard error of the mean (SEM) ( n = 3/group). # p < 0.05 vs. Con group. ## p < 0.01 vs. Con group. ∗ p < 0.05 vs. IL-6 group. ∗ ∗ p < 0.01 vs. IL-6 group. △p < 0.05 vs. Magnolol group. △△p < 0.01 vs. Magnolol group.

Article Snippet: The primary antibodies in western blot were as follows: Anti ‐α- MA (catalog number: 19,245), anti ‐STAT3 (catalog number: 12640S), nti ‐phospho ‐STAT3 (catalog number: 9145S), anti ‐total ‐JAK2 (catalog umber: 3230S), anti ‐phospho ‐JAK2 (catalog number: 3771S) antibodes were obtained from Cell Signaling Technology (Danvers, MA).

Techniques:

Fig. 10. The mRNA expression of the JAK2/STAT3 signaling path- way in the A549 cells. (A) HIF-1 𝛼mRNA expression. (B) 𝛼-SAM mRNA expression. Data are expressed as mean ± SEM ( n = 6/group) #p < 0.05 vs. Con group. ## p < 0.01 vs. Con group. ∗ p < 0.05 vs. IL-6 group. ∗ ∗ p < 0.01 vs. IL-6 group. △p < 0.05 vs. Magnolol group. △△p < 0.01 vs. Magnolol group.

Journal: Chinese Journal of Analytical Chemistry

Article Title: Active substances and molecular mechanisms of Astragali Radix and Angelicae Sinensis Radix against idiopathic pulmonary fibrosis effects by network pharmacology and in vitro experiments

doi: 10.1016/j.cjac.2024.100397

Figure Lengend Snippet: Fig. 10. The mRNA expression of the JAK2/STAT3 signaling path- way in the A549 cells. (A) HIF-1 𝛼mRNA expression. (B) 𝛼-SAM mRNA expression. Data are expressed as mean ± SEM ( n = 6/group) #p < 0.05 vs. Con group. ## p < 0.01 vs. Con group. ∗ p < 0.05 vs. IL-6 group. ∗ ∗ p < 0.01 vs. IL-6 group. △p < 0.05 vs. Magnolol group. △△p < 0.01 vs. Magnolol group.

Article Snippet: The primary antibodies in western blot were as follows: Anti ‐α- MA (catalog number: 19,245), anti ‐STAT3 (catalog number: 12640S), nti ‐phospho ‐STAT3 (catalog number: 9145S), anti ‐total ‐JAK2 (catalog umber: 3230S), anti ‐phospho ‐JAK2 (catalog number: 3771S) antibodes were obtained from Cell Signaling Technology (Danvers, MA).

Techniques: Expressing